Journal: Diagnostics

Article Title: Comparative Immunohistochemical Analysis of FAP and c-MET Expression Across Renal Cell Carcinoma Subtypes: Preliminary Results and Potential Theranostic Implications

doi: 10.3390/diagnostics16193228

Figure Lengend Snippet: FAP expression across histopathological subtypes of renal cell carcinoma (RCC). ( A – C ) Representative hematoxylin and eosin (H&E)–stained micrographs illustrating the characteristic histomorphological features of clear cell RCC (ccRCC, ( A )), papillary RCC (pRCC, ( B )), and chromophobe RCC (cpRCC, ( C )). ( D – I ) Representative images of FAP-immunostained sections of ccRCC ( D , G ), pRCC ( E , H ), and cpRCC ( F , I ) showing low ( D – F ) and high ( G – I ) levels of FAP immunoreactivity within the tumor center. ( J – L ) Representative examples of low FAP expression in the peritumoral region of ccRCC ( J ), pRCC ( K ), and cpRCC ( L ). ( M – O ) Representative micrographs demonstrating high peritumoral FAP expression in ccRCC ( M ), pRCC ( N ), and cpRCC ( O ). All images were acquired at 20× magnification; scale bar = 100 µm.

Article Snippet: Sections were finally counterstained with hematoxylin (Vector Laboratories; H-3401), dehydrated, and mounted.

Techniques: Expressing, Staining

Journal: Diagnostics

Article Title: Comparative Immunohistochemical Analysis of FAP and c-MET Expression Across Renal Cell Carcinoma Subtypes: Preliminary Results and Potential Theranostic Implications

doi: 10.3390/diagnostics16193228

Figure Lengend Snippet: c-MET expression across histopathological subtypes of renal cell carcinoma (RCC). ( A – C ) Representative hematoxylin and eosin (H&E)–stained micrographs showing the typical histomorphological features of clear cell RCC (ccRCC, ( A )), papillary RCC (pRCC, ( B )), and chromophobe RCC (cpRCC, ( C )). ( D – F ) Representative images of c-MET–immunostained sections of ccRCC ( D ), pRCC ( E ), and cpRCC ( F ) showing low c-MET immunoreactivity. ( G – I ) Representative examples demonstrating high c-MET expression in ccRCC ( G ), pRCC ( H ), and cpRCC ( I ). All images were acquired at 20× magnification; scale bar = 100 µm.

Article Snippet: Sections were finally counterstained with hematoxylin (Vector Laboratories; H-3401), dehydrated, and mounted.

Techniques: Expressing, Staining

Journal: Diagnostics

Article Title: Comparative Immunohistochemical Analysis of FAP and c-MET Expression Across Renal Cell Carcinoma Subtypes: Preliminary Results and Potential Theranostic Implications

doi: 10.3390/diagnostics16193228

Figure Lengend Snippet: c-MET and FAP expression in non-neoplastic renal tissue. ( A ) Representative hematoxylin and eosin (H&E)–stained micrograph of normal renal parenchyma showing glomeruli (*), renal vessels (V), and proximal (#) and distal (^) tubules. ( B ) FAP expression is absent in non-neoplastic renal tissue. ( C ) Variable c-MET immunoreactivity is observed in epithelial cells of proximal and distal tubules, in the capillary loops of glomeruli, and in vascular structures. All images were acquired at 20× magnification; scale bar = 100 µm.

Article Snippet: Sections were finally counterstained with hematoxylin (Vector Laboratories; H-3401), dehydrated, and mounted.

Techniques: Expressing, Tissue, Staining